The breadth of pathology within the scope of ocular oncology spans all ocular, orbital, and adnexal struc¬tures. As such, the clinical assessment of patients must be accordingly comprehensive and tailored for the detec¬tion and surveillance of neoplastic processes. While the essential modalities of standard ophthalmic examination are utilized in the practice of ocular oncology, a nuanced perspective is necessary to optimize management for this subset of patients. In this chapter, we present the system¬atic approach to clinical examination employed at The New York Eye Cancer Center as a basis for the assessment of patients in ophthalmic oncology practice.