Techniques for delivering chemotherapeutic agents for intraocular tumors have evolved. In addition to the traditional intravenous chemotherapy, more localized intra-arterial, periocular, and intravitreal chemotherapy (IVC) techniques place chemotherapeutic agents into the eye. Ocular chemotherapy achieves maximum local drug concentrations, improves efficacy, and minimizes adverse effects.
RB and vitreoretinal lymphoma are 2 intraocular tumors where periocular and intraocular chemotherapy are widely used. This chapter focuses on the medications and techniques of ocular chemotherapy.